Won't prevent audiophiles from being audiophiles. I remember reading a screed against double-blind testing on some magazine (would link to, but can't find it)
I had a huge problem of making an D/A converter with enough precision for instrumentation a while back, but designing some digital I/O with enough bandwidth for it was a nightmare. Then I looked at the Internet and saw an audiophile complaining that a soundcard[1] with 20dB less noise than my design was crap.
1 - A PCI express card, of course. Didn't try that bus. I'd have a really bad time manualy creating a board for it.