As an example of how this could be possible, imagine the population of the USA were 3: two people living in East St. Louis, and one person living in Hawaii.
Distance, as well as population, is a factor in the mean center of population. Even today there isn't close to a majority of the population living west of the Mississippi.
[1] http://wiki.answers.com/Q/What_it_the_population_west_of_the...