[cgriswald]

In the particular case of founders it may be that simply having others (outside their fellow founders) to talk to about their problems might stem off the depression in the first place. Isolation is great for causing depression, especially in the presence of all kinds of stresses and pressures.

Once it passes into depression it simply doesn't matter whether it is "founder depression" or any other kind of depression. For true, major depression, therapy is an absolute must. Pharmaceuticals may also help in the short term. Anything else, including all the awesome people offering an ear in this thread, need to be in support of the professional help.