[neurostract]

> Both Ritalin and Adderall are dopamine reuptake inhibitors.

Methylphendiate (Ritalin) is a dopamine reuptake inhibitor, to be certain: it binds to and blocks both dopamine and norepinephrine reputake inhibitors. It's thought to increase neuron firing rate, but that mechanism of action is unknown.

Adderal, however, is a mixture of dextroamphetamine and levoamphetamine salts. They stop reuptake of the two monoamines not by blocking the transports, but by reversing their action. Instead of taking up dopamine and norepinephrine, they pump it out. It also stimulates the release of the monoamines from the synaptic vesicles into the intracellular membrane.

Ritalin causes dopamine and norepinephrine to stick around longer, making their action last longer. It's like closing a drain half way with the faucet on medium: the water level rises more than typical, but no higher.

Adderal causes them to flood the intracellular fluid. It's like turning the faucet on while flood waters are coming up the drain pipe.