[krschultz]

"But the inability to replicate the experience in full, I think , inhibits catering to that demographic."

That makes me think of trying to see what it feels like to be inaccessible user, I'm picturing a VM that makes the screen fuzzy or something.

If all you want is a VM with the tools installed - that's pretty simple. I imagine every developer can make a VM with an OS in it, and there are plenty of free accessibility tools available for the OS of your choice: http://usabilitygeek.com/10-free-screen-reader-blind-visuall...