[mileswu]

For high-energy experimental physics (HEP or particle physics), most tend to use a CERN developed C++ framework called ROOT[1]. It's not overly pleasant, but it gets the job done.

There are Python bindings to ROOT (pyROOT) but I've found Python in my experience to be a bit too slow when handling the large (10TB+) datasets.

As an aside, it's interesting how ROOT attempts to provide C++ with some basic reflection[2] and saving of C++ objects to dis. Unfortunately it doesn't necessarily do a very good job of it, but perhaps things will change with ROOT6 as it transitions to being based on clang, as opposed to in-house C interpreter.

[1] http://root.cern.ch/ [2] http://root.cern.ch/drupal/content/reflex