[DanielBMarkham]

tl;dr: We choose to give life meaning. It is our choice of assignment of meaning (or not), that is the only thing to be discussed here. (Yay existentialism!)

When you think about the incredible number of galaxies, each with hundreds of billions of stars, having untold habitable planets, existing for tens of billions of years? Then we think about our one planet Earth, and how each of us lives only 50-100 years and then we're gone?

We have the question backwards. In the grand scheme of things, we're much less than a speck on a mote somewhere, a fruit fly. We're completely inconsequential. It's not for us to ask what life is about. We have the question backwards. Instead life -- that thing that has existed for eons before we were ever a possibility and that will exist eons after our memory is gone -- is asking us "What is the meaning of you?"

Life sets us up with initial conditions and gives us various challenges as we go through our minuscule little part of it. It is during these experiences that Life is asking us what our meaning is. Our choices provide the reply.

Being alive is answering the question: what is my meaning? We could no more judge the meaning of life itself than we could begin to count the habitable planets in the sky. To phrase the question in this way is just to provide busywork instead of dealing with the reality in front of us.