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When I hear "the perfect is the enemy of the good" it's usually in response to the sentiment, "I can't ship this yet; it's not 'perfect'".

In the context of this article: You have a patient who needs to be treated -- today. They can't wait for a hypothetical perfect treatment. Indeed, more fundamentally, the only way to discover a "perfect" treatment would be to use today's least-worst solution, with the determination to measure and improve it continually.

Also the point of the article was that it's not so much the techniques -- which all the CF centers know about and use -- but the aggressiveness of their consistent application.

This isn't about a perfect design. It's about doctors who are willing to coach/goad/persuade patients into doing consistently what they already know they need to do. (And who are willing to be sticklers for consistency to the point of being a bit of a PITA to their colleagues.)