[cjo]

It might not be easy, depending. Without too much trouble you could write a macro for this:

    (my-macro "
    foo
       bar
    baz beez
       zang
          dang
          bang")

and have the macro parse the string manually into something the eval/apply loop understands. But I think it might get funky pretty quick, and you'll likely lose a lot of power in the process.

The example of Hiccup above doesn't add anything new to Clojure's syntax, the DSL is all legal Clojure data structures. That way it inherits all of the power of the underlying language, like if you want to dynamically generate new HTML - that functionality comes from Clojure. But doing that while modifying the syntax for meaningful whitespace wouldn't be easy.