I don't see why not in theory, but in practice GRUB2 is the only available option out-of-the-box. I'm curious why you're so interested in this, though. Care to explain your ostensible desire for an alternative bootloader?
I understand it reasonably well and am hesitant to switch.
I have tried others and have not been impressed.
I am a connoiseur of bootloaders I guess.
It's an important program, maybe the most important one.
Based on my limited knowledge of other computer users, I
believe we all have what we consider a "trusted" program
that does some task for us over and over again. We come
to rely on it and appreciate it (for our own idiosyncratic
reasons). We are hesitant to switch to something else.
The bootloader I use can boot Xen kernels; no need for GRUB2. Is the Qube boot process described somewhere?