If someone is wondering, Qubes (and all Linux based distros) are not Macbook friendly [1]. But honestly, if security or privacy are a priority for you then you are probably not using a Macbook anyway.
Why would you not be using a Macbook if you want security or privacy?
If you are referring to Mac OSX and its integrations with App Stores and social media systems, note that it is entirely optional (I don't use any of the social media guff bundled into the OS).
Unless you are referring to something else and think that buying a piece of hardware somehow means you don't care about privacy, regardless of which software you are running on that piece of hardware?
If security and privacy are of absolute priority to you (journalist, activist) then using a OS with closed source essentials is absolutely absurd.
If security and privacy are of some importance to you then using a OS with closed source essentials due to ease of use or development environment only increases the number of years until a strong privacy easy to use OSS system gets rolled out more widely. Your actions have broader impact than just your priorities.
Finally, there is more than just the software. Getting closer to the metal you have to contemplate bootloaders trust and verifiability.
Personnally, I would not be speaking about Apple hardware, I don't know it well enough. But in general, hardware is relevant to security, simply because most of them nowadays contain firmwares. In some cases, that firmware can even be a small embedded OS. If that particular piece of software happens to deal with inbound data (think WiFi controller), then you have a potential security hole _which you have no control on_.
If you are referring to Mac OSX and its integrations with App Stores and social media systems, note that it is entirely optional (I don't use any of the social media guff bundled into the OS).
Unless you are referring to something else and think that buying a piece of hardware somehow means you don't care about privacy, regardless of which software you are running on that piece of hardware?
I don't think the piece of hardware is relevant?