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by chewychewymango 4452 days ago
It's obvious you don't know very much about serotonin. Here's why:

SSRIs bind to the serotonin transporter SERT. The 'selective' part means that it has a much higher affinity for SERT than other monoamine transporters (e.g., DAT or NET). Although you're correct that there are various serotonin receptor subtypes, there is only one known SERT (there is only one gene).

SSRIs do exhibit extremely weak affinity to serotonin receptors but it is so low that it doesn't matter which subtype has a higher affinity than another. If you want to latch on to 5HT receptors with interesting ratios and affinities, the correct psychiatric drug would be an antipsychotic.

Please stop defending the chemical imbalance model when you do not understand the science at all. Thank you.