[royprins]

Is that a problem in any other watch? Left or right wrist, the 12 stays on top. Only the button is on the other side.

Besides that: don't count on it. If you pay close attention, you see that the bottom part of the round screen stays black. Most likely to accommodate the controller for the screen. Upside down will not work for that reason.

In a square watch, it might.

[DEinspanjer]

Yeah, normally, you have two options, just wear the watch with the stem pointing inward which means you have to reach over the watch face to use it, or buy a special watch with a left handed stem. You can't just rotate the watch 180 and wear it with the stem facing outward because the numbers would be upside down.

With a completely digital display though, theoretically, it would be possible to rotate the watch and have the display rotate as well. The clasp would still potentially be upside down, but depending on the type of clasp, that doesn't matter much.

As you said, if the controller face of the screen is dedicated and not able to be rotated as well, that wouldn't work.