This will deattach and reattach a tmux session. You can type ``tmux detach`` inside a tmux pane of the session you want to detach. Also the key combo ``Ctrl-b d`` will detach.
If you mean a way to save the workspace configuration, tmuxp, teamocil and tmuxinator are great solutions.
(Note, I wrote tmuxp as a python project a few months ago.)
The one downside to tmux over screen is that tmux basically requires that all clients connecting to it have the same screen size, and by default it chooses the smallest one. So while you can connect to an existing session, the output might be ugly.
For this reason, I typically simply 'tmux detach;tmux attach"
Tmuxifier (https://github.com/jimeh/tmuxifier) is a great utility for scripting tmux layouts. Well worth checking out if you have complex layouts you want to be able to recreate.
If you mean a way to save the workspace configuration, tmuxp, teamocil and tmuxinator are great solutions.
(Note, I wrote tmuxp as a python project a few months ago.)