To a right-handed person it does ...I imagine to a left-handed person it must feel like the cursor/pointer is pointing the "wrong" way. I am wrong on this lefto weirdies? Bonus upvotes for casual slur surely.
My door handle is a knob that turns both ways to open, but turning my right hand (I'm right handed) clockwise is far more comfortable than doing so counterclockwise.
Ha ha ha! Thanks for your advice. I shall now be able to enter my bedroom again.
Seriously, though, I felt it obvious but I'll spell it out. Some doors open only one way. That way is likely more comfortable for right-handers. Having a doorknob which moves both ways, I have been able to observe that there is a difference in the 'feel' of the way it opens depending on the direction. I offered this as information so you could answer your question yourself.
This is why the first thing I do on a new machine is make sure I can switch the arrow to point right for when I'm mousing with my left hand.
Some systems make this easy (click the 'flip cursor' box, done!). Others make you spend an hour trying to figure out where to get custom cursors and how to install them. >:(
I'm right-handed in most respects, but my preference on a desktop is to operate a trackball with my left hand. I've never even thought about this "problem".