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My colleagues and I learnt that lesson the hard way. We are working on a WYSIWYG editor (Aloha-Editor) and the first version did depend on jQuery (and jQuery UI for that matter). That caused a lot of trouble for people integrating the editor in their websites, especially if they were already using jQuery. For our particular case we really didn't need it, as it's just as easy to say .getAttribute() instead of .attr(), and we didn't use selectors much, if at all. Effort is underway to get rid of the dependency from the core library in the next major release.