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by rgejman
4532 days ago
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I think that they will incubate CD8 and CD4 T cells from the same mouse together. The CD8 (cytotoxic) T cells, if they recognize the antigen, should kill the infected CD4 cells. A caveat is activation/co-stimulation. The CD8 T cells should already be activated due to the vaccination and no longer need co-stimulation from DCs... but this depends on the vaccine having delivered enough peptide to stimulate a true immune response in a human/humanized immune system. That's the (first) big unknown here. |
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