[edhebert]

Try remapping it so that the Command buttons, i.e., the keys next to the Space Bar, are Control. This was the position of the old Symbolics machines. To my hands, it makes Emacs much more efficient, since the rest position for the thumbs can be between the Space Bar and the Control keys.

[Derbasti]

I tried that and it worked great for Emacs, but it messes with normal OSX operation.