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by dzhu
4545 days ago
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Warfarin sensitivity is _precisely_ why 23andMe needs to be regulated; 23andMe has NOT clinically (or analytically) validated any of the claims around the specific SNPs they've identified. All 23andMe does is link to research papers that may suggest that there are gene variants that are linked to warfarin sensitivity; however, these have not been validated to be clinically significant. In fact, just last month, the New England Journal of Medicine published a landmark study around the pharmacogenomics of warfarin dosing, which found that this very genetic data does NOT affect/improve warfarin dosing (http://www.nih.gov/news/health/nov2013/nhlbi-19.htm, original paper: http://www.nejm.org/doi/full/10.1056/NEJMoa1310669). In light of this, this warfarin sensitivity information that you've obtained from 23andMe is almost certainly a false positive, and if you were on a prescribed warfarin treatment, 23andMe would've likely resulted in a change in your behavior that would be strictly detrimental to your health. |
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I don't think there is any valid basis for that claim. A rational person (and I only mean "somewhat rational", I'm not talking about an Econ101 "perfectly rational actor" here) would get their 23andMe results, go "hmmm, this is interesting" and line up a visit to their primary care physician to talk about the results, and what it might mean for their treatment... at which point additional tests might be indicated, or the doctor could more fully explain the various tradeoffs, implications, etc.
There's no particular reason to assume that people are going to randomly adjust their medications based on 23andMe results alone.
And, even if they do, so be it - the price of personal freedom is individual responsibility for the outcome of your actions.