[bdcravens]

The culture of San Francisco also is heavily accepting, even promoting of smoking marijuana.

Your startup is in SF, so this is probably relevant, but there's absolutely nothing that requires a startup to be in SF. It can be in Austin, Brussels, Sydney, Fargo, or Bangalore. If you feel that local culture acceptance is a reason for, then you've already answered the question if you start up in a locale where it isn't.