[arbitrarilyHigh]

I generally agree with your criticisms, but what alternative do you propose? Of course we should have better vetting of studies before publication, more replication effort, and ideally a process that doesn't incentivize fraud/incompetence. But how to implement such a system? Also, I don't see how these issues are limited to animal studies. Your (entirely valid) criticisms of bias, uncaught error, and irreproducability apply much more broadly, to the vast majority of published modern experimental science, again raising the question of how we can address those issues so that the scientific literature is reliable.