Startups for the Rest of Us (Rob Walling and Mike Taber, largely targeted at people who are pre-product on SaaS), Tropical MBA (eclectic small/Internet business topics), Boostrapped with Kids (two guys with bootstrapped startups), Bootstrapped.fm (two other guys with bootstrapped startups), and a few others, but those are more than enough to match my coffee/gym time these days.
If someone else tries to search for these in the Podcast app, "Bootstrapped.fm" is just "Bootstrapped" on there and the search fails to find it using the complete name/domain.
TWiT http://twit.tv/ I am selective about it though, Windows Weekly, some of the Floss weekly, some of Security Now and TWiT itself only if Dvorak, Calacanis or Adam Curry are on (sadly 2 of them appear to have been blacklisted).
I've been listening to EconTalk with Russ Roberts[1], The KunstlerCast [2] and Poetry Magazine podcast [3] for years. Good stuff. It'll put hair on yer chest.
I love the Slate Political Gabfest. I attended a live show in Chicago, and it was great fun; I strongly encourage anyone who likes the show (and/or who is interested in politics) to attend.
1.) Manager-tools - For management. No fluff and actionable info.
2.) Stanford Entrepreneurship thought leaders - For Startups
3.) 99% invisible - For design
4.) Ted Talks - For knowing brilliant people
5.) Security Now - IT Security
Unfortunately on yesterday's episode Gina and Kevin announced that next week will be their last In Beta, and someone else is taking over the show. Curious who it'll be, but definitely won't be the same.