I've been using GrandPerspective for quite a long time. Pretty happy with it, lots of ways to drill down deeper / filter / etc to get at what you're looking for.
Ah, I have used both, but I also haven't been using OS X for the past couple years. One of them, I didn't remember which, was actually a PPC program that required a Rosetta to work. At some point it stopped working, and I switched to the other.
Since I hadn't used them in a while, I forgot which was which. However, some further research says that Disk Inventory X was the PPC program. In that case, I'd also recommend GrandPerspective.
http://www.uderzo.it/main_products/space_sniffer