[neomindryan]

I'm throwing in my vote for Philadelphia. We've got a great tech scene, cheap rent and easy access to New York, DC, and Baltimore (just in case). We have the most bicycle commuters per-capita in the USA and great restaurants, bars, and live music. The city is increasingly interested in fostering the tech / startup community, and there are major universities in town that provide talent and venues (I'm at a hackathon at Penn today, Drexel hosts the Tech Breakfast meet up every month).