[epistasis]

Thank you for a very informative and helpful reply! However, I would like to see this work validated before I fully accept his conclusions.

Regarding the 24%, if you look in Table 2 of that study, of the 12 that were "unchallenged and unreplicated", the notes for 10 list follow on studies that would reveal problems with the initial study, were the initial study to be "wrong."

That leaves 4% that are "unchallenged and unreplicated" yet have 1000 citations. So I would be quite interested to know the take of the researchers in the field on those papers, and if they would agree with Ioannidis' assessment on those 2 papers.