[dnautics]

Genome compiler is not a good example. The fundamental premise is incorrect. Biology should not be done as a drag-and-drop exercise... Saving a few minutes of your time is not worth having blinders that increase the likelihood of huge errors in your design. Having an intimate and comprehensive knowledge of your sequence is critical, and having a casual knowledge can lead to disaster. This is not for just anyone, either, you also have to have instant, library recall of as much as possible.

To give an example, I once witnessed an algorithmic redesign effort completely miss two extragenic components in an essential gene that would likely not have been missed by an attentive human (or better yet two or three attentive humans). Luckily, the cells evolved their way around it, the researchers tracked down the problem and how the bugs solved it and the situation is interesting enough to possibly result in a publication.