[GFischer]

From an entirely outside experience, I saw at the company I work for a very bad experience with a project where the team pushed for a single page application - they got delayed for months because of the technology, the problem was not single page applications in themselves, but that they seriously underestimated the learning curve and they were absolute novices (no-one had prior experience in SPA). And I definitely believe they could have cut months from the development time by sticking to known tech.

For a company where development is not core, I wouldn't recommend it, but if the company is a tech company, I would evaluate devoting resources to learning single page applications and doing some pilot projects, then leveraging the experience and pushing it into the main projects if applicable :) .