[oellegaard]

So far - for development - I haven't had any issues with the case sensitive file system. I guess it's because in the end of the day, it's all tools made to work on Linux I use.

If you're using OS X for an all-round machine, it might be the wrong choice.

[Xylakant]

Apple themselves used to discourage using a case sensitive partition for the OS. It's probably fine, just not the standard and widely tested configuration. The major hassle starts when one single program you need fails because of the setting - you'd just have to reinstall everything. So the safer way is use case insensitive for the primary and have a dedicated space for development with a case sensitive FS.