[corruption]

Hopelessly optimistic. Spoken like someone who has never taken an experimental design course imho.

1) The search space is practically infinite dimensional. All methods suck when trying to extract a causative model from an infinite search space. There's a reason why in experimental design we change as little as possible.

2) SNP's are not the entire story. If it were this simple we would have progressed much further already. See dismal failure of all other high throughput sequencing and microarray technology. We still don't know how to analyse this stuff properly, if it will ever be possible.

3) The metabolome is adaptive! While we each have different enzyme kinetics due to slight differences in protein makeup, overall metabolic flux rates are amazingly consistent. See Oliver Feihn et al for more details.