[pkamb]

Your hands and forearms should be hitting the keyboard at an angle, due to the way your elbows hang outside your shoulders. Don't bend the wrists to make your hands go perfectly vertical; that's a major RSI concern.

At that angle, the U/J/M and I/K/Comma rows, etc., should line up pretty well with the bending of your fingers. Same with E/S/Z and R/D/X. But Q/A/Z (how most people type) requires a completely unnatural bend!