[krapp]

I would suggest that this in particular is a problem with your workflow and IDE/editor and not PHP. I've usually just kept everything open as a project in Sublime Text, works just fine. As far as the code itself goes, using PSR-0 and/or Composer makes most of the headaches with class loading just go away.

[inthewind]

I agree about that PSR-0 and using Composer helps. But sadly not all code is written that way.