Isn't that covered by the caveat contained in the point? ... (You can choose not to be profitable, but it must be your choice, not something forced on you by the market).
I think some business models only make sense at scale. While the caveat does apply to facebook (they probably could have been a profitable niche student social network) occasionally I see businesses that it just doesn't make sense to even start unless you plan on getting really big. Examples would be PayPal, Google and Spotify.