[w3pm]

Here you go:

http://money.cnn.com/calculator/pf/cost-of-living/

Enter St. Louis, MO and San Francisco, CA. Housing is 276% more expensive. Columbia? 252%. Kansas City? 215%. You get the idea.

Also, just for fun, try some other "large towns":

Dallas, TX: 276% Columbus, OH: 268% Austin, TX: 245% Jacksonville, FL: 242% Phoenix, AZ: 225% Atlanta, GA: 217%