[cnp]

Anxiety is a difficult one to get around, but that said it might greatly ease that issue, too.

I wouldn't recommend trying them alone without someone who knows the space (very well) and can guide you if your anxiety begins.

Physiologically, aside from maybe a tiny bit of stomach discomfort in the beginning, they're harmless, less neurologically damaging than a glass of wine.

[NhanH]

Know the space, as in know the experience of using one, or did you mean knowing the geological space of the location so they can physically stop you from doing silly thing? (Just out of curiosity, as I have no idea how one act under influence)

[cnp]

No, meaning they know the headspace of the trip. Experienced psychedelic users understand how to get through the anxiety and fear should it arise and incorporate it back into the trip as opposed to fighting it, and know how to communicate that to others.

Bad trips happen, but studies have concluded that given the right set and setting --meaning, feeling secure in your environment-- the risk of such is greatly lowered.

Keep in mind that the vast majority of people have good experiences as long as they come prepared.