[dnsbty]

I like to just follow people whose tweets I actually want to read to begin with. Before following anyone I check their last few days worth of tweeting to make sure they don't post junk and that I will be interested in what they have to say. Twitter is not meant to be a friendship or connection manager like Facebook or LinkedIn so much as it is a way to get concise info delivered quickly. Obviously it can be a great networking tool, but by getting others to follow you by sharing good content, not by following junk tweeters in the hope that they'll follow you back. If you're too afraid to unfollow those whose tweets are junk you're not using Twitter correctly.

Edit: That being said, I feel like a client that would let people sift through tweets more efficiently could be great for those who don't agree with me and end up following 10k+ people, and that approach definitely isn't uncommon.