[talles]

I'm not that experience with responsive design, but recently I wondered that myself and, for what I saw, I concluded that is too much effort to make it responsive in that level.

Responsive feels great with huge/big/medium displays. With tiny ones I would go with a specific layout (like github did).

[foca]

Yeah, it definitely depends on the use case. Some websites just "make sense" on responsive layouts. Others… not so much :)