[Retric]

Forcing a comparison to existing drugs sounds good, but things that are less effective but have fewer side effects are often far more useful than the most potent option aka Tylonol vs Morphine. The problem is you still need the placebo baseline or saline would pass as the safe but less effective alternative. Now, adding competing drugs to a trial is great information the problem is they are already really expencive so adding even more cost is generally a hard sell.