[yk]

Judging from the last two space operas i have read, the fashion is sending transhumans on single generation ships ( and playing with internal clocks to manage the subjective boredom).

And there are certainly a few people looking at interstellar travel. A great blog about this is

http://www.centauri-dreams.org/

[jlgreco]

Charles Stross's (HN: cstross) Accelerando has a nice treatment of this.

I think Orion ships are something that we could attempt to start building today though, no need to wait until the singularity.