No, I believe most of these "Lets Play" videos contain commentary voice-overs by the players, but neither they nor Google care about this with the Content ID system.
I'm not a copyright lawyer, but that sounds like an unauthorized derivative work. For fair use to apply, the work has to be transformative, changing the original work in a substantial way. Since I'm not a lawyer I don't know if recording your own voice over the video would be considered significantly transformative or not.
The original work is an interactive piece of software.
The videos in question are people showing what can be done with something which is copyrighted. They videos don't provide any ability to play the game. The games are only being played by a single person. There is no copy of the game being made.
A running commentary of a single played instance of a game is entirely different than sitting down with a controller in your hand and playing the game. That seems significantly transformative to me.
The audio/visual aspect is kept. Interactive gameplay is simulated. The person watching gets to see the story unfold. It's clearly a derivative work, the question is where does the line stand and does making a LP cross it?
And that's a huge problem with copyright law, it's so grey in so many areas. If the exact situation hasn't been defended in court, it's unclear whether or nothing something is legal.
The story playing out is one thing that makes it a tough call where the line could be drawn.
What if it isn't a RPG? What if we're talking about a video of mario kart?
If I bought a physical Nintendo chess set, I don't think anyone would claim a video of my gameplay would be Nintendo's property. By extension, a video of me playing a virtual nintendo chess game with my commentary should still be mine, after all, the story is being written by the players. I think that's fairly analogous to a commentary of a mario kart game.
Now it gets interesting with a role playing game like zelda perhaps. I certainly have a right to produce a gameplay from it. Do I have a right to record it? Why not? How is it really any different that recording a play with a physical object, something which is done every day. Nintendo may have the storyline, but they didn't create the actual play. That is a result of an authorized use of the game. Player runs over here, picks up a sword -- that's something the player did, not Nintendo.
I think in the end it boils down to what the lawyers can convince a judge is true, rather than what can be proven or what is the law.
IANAL either, but I'd say it's pretty transformative. It goes from binary code and assets you can interact with to a video with commentary.
Song mashups already go from songs to similar-sounding songs and those are fine. Again, IANAL, but if mashups are okay, it makes sense to me that Let's Play videos should fall under the same - if not more generous - rules.
But legally mashups aren't okay. Bridgeport Music, Inc. v. Dimension Films was a sucessful suit over a two-second sample. The court decided that unlicensed use of even this brief riff was infringement. Mashups are tolerated because of their place in musical culture, but if a copyright owner decided to sue they'd have an easy case. (Though maybe not from a PR perspective.) (I'm also not a lawyer.)