But, having an extension like Stylebot installed and using a tiny custom CSS does offer an advantage - the CSS applies across the domain and takes effect every time the page is loaded.
Yes, though it's slightly more complex than that: if you've got multiple tabs open, you'll probably want to resize the window again to view the other tabs, and (at least in Chrome) if you open a new tab or window it'll also have that increased font-size which you'll have to decrease again.
But, having an extension like Stylebot installed and using a tiny custom CSS does offer an advantage - the CSS applies across the domain and takes effect every time the page is loaded.
For example, see this gallery - http://imgur.com/a/MxFtD