[michaelbuddy]

If you work on Windows and want something with full vector graphic drawing, take a look at Xara Designer Pro or Xara Web Designer Premium. You'll have drawing capabilities like with Illustrator, but it's faster and you can assign things as buttons and mockup working websites.

You can make working dropdown menus too.

It produces a lot of absolute positioned css code, so it's not integrated with any web framework but does render pixel perfect.

I'm not sure how it would handle a responsive site, probably not, but you could quickly mockup the mobile version though.

You might also look at Corel Draw too.

If you want free, again Pencil, Inkscape or try the Google Draw templates - http://mortenjust.com/2010/04/19/a-wireframe-kit-for-google-...

another recommend for draw.io and also look the maqueta software - http://maqetta.org/news/2011/ibm-contributes-maqetta-html5-v...