[Offler]

Of course you can use JavaScript to express OOP patterns. You say it yourself that you need those patterns to develop large apps. Anyone who does otherwise either leaves behind a mess of a code base or is being naive. You can have classes right now in JavaScript, it's just a matter of educating developers.

[Offler]

Where I work we have build a framework which is quite powerful for handling large JavaScript codebases. http://www.caplin.com/developer/component/bladerunner

I'm surprised there isn't an equivalent OS one, I think Yeoman is a pale comparison of it.