[svenk]

Klaus Knopper, the maintainer of the Knoppix distribution has a blind wife. She uses Knoppix with some extra modules and it works very well. A synthetic speaker reads everything whats important on the screen. You should definitely checkout http://www.knoppix.org/

[svenk]

The project for blind people is called ADRIANE - Audio Desktop Reference Implementation and Networking Environment http://www.knopper.net/knoppix-adriane/index-en.html