[danneu]

Cocaine and amphetamine result in the same flood of the same neurotransmitters. Cocaine has no surprises for anyone that's ever been cracked out on instant release speed. Except maybe making them go "...is this it?"

Lots of overlap between the two, especially when comparing pharmacophores. For instance, the peptide transcript called the "cocaine- and amphetamine-regulated transcript (CART)"[1] might be a good example.

Not to say that you personally haven't had different experiences with the substances. There's just substantial chemical/physiological overlap between the substances while there's much less demographic/prescription/intended-effect overlap.

[1]: http://en.wikipedia.org/wiki/Cocaine_and_amphetamine_regulat...

[throwaway04583]

I have had substantial experience with both of them, and while the effect is similar, the feeling is not. In my experience, cocaine has a stronger euphoric component than d-amp. Adderall makes me logical and emotionally detached, while cocaine makes me feel like I'm on top of the world.

I think the reason for using the substance could be coloring my opinion of the experience, since I use adderall to get work done, and when I use cocaine (not often, maybe once or twice a year. I did a decent amount of blow when I was doing opiates heavily), it's almost always in a social setting.

I will grant that the pharmacological effects are very similar.