[eduardordm]

Also consider that depression sometimes is 'latent' and the startup roller coaster can be the triggering factor. My first co-founder (and lifetime friend) committed suicide a year after leaving the company to become a federal agent. We could never have guessed he was suffering from severe depression.

People seems to think that depression is a personality issue/characteristic, not an actual decease. Depression is a curable decease that sometimes can even be detected with blood and saliva tests. It requires medical attention and almost every case ends up in drug treatments.

If your doctor understands what a startup is and allows you to do it, I don't see why you shouldn't. You can't scape from depression by not doing a startup.