[awolf]

Very interesting. Am I understanding this correctly: it's an insulin replacement? Those treated would have effectively no insulin in their blood stream?

If so, wouldn't those treated by this gene therapy still suffer a persistent hormone imbalance? Hormones are complicated. Insulin (and the lack thereof) is tied in up-down regulation of lots of other hormones. Glucagon, for one, would always be higher in your body meaning you'd be prone to break down your body's fat stores. While that might actually be a positive side effect, I wouldn't be surprised if there were many negative side effects too.

Still, the side effects from this hypothetical hormone imbalance is very likely a huge improvement over constantly having advanced glycation end-products slowly destroying your body (which is what slowly happens to us type 1 diabetics).

[lloyddobbler]

It's a bit poorly-worded...but looks like it says the therapy does 2 things: 1) It expresses the insulin-producing genes (insulin is the protein hormone that binds with glucose in the blood to convert it to ATP, or energy), and 2) it expresses the Glucokinase genes (Glucokinase is a hormone that regulate glucose uptake from the blood).

(I know you're type 1 - me, too - but wanted to explain it further for those who don't know how it works.)

Agreed on the hormone imbalance side of things. The Glucagon issue seems very real. However, if it's in essence stimulating insulin production as well as improving the glucose uptake, then that in turn should balance the blood sugar effects of Glucagon. As for the other effects, though...that definitely remains to be seen.

[nitrogen]

It looks like the therapy introduces the genes for production of both insulin and glucokinase, so yes, there is still insulin, but not injected insulin.