[sootzoo]

I assume you mean: in a simulator, in a light aircraft (e.g. a small Cessna or Piper or something similar).

In a heavy aircarft, e.g. passenger airliner? Has this even happened?

[cynest]

AOPA is purely general (non-commercial) aviation, so the first point is correct, although iirc the data was from actual incidents.

I don't know if anything like that has ever happened in a heavy aircraft. However, commercial pilots have pretty big health requirements to make situations like that less likely.