[stephencanon]

Because the location of my wife's job is completely non-negotiable (she's a surgical resident), whereas there are no actual impediments to me doing my job from anywhere with an internet connection.

As for the isolation during working hours, it makes me fantastically productive -- no junior coworkers sticking their head into my office to ask questions they could answer themselves if they thought about it for a couple minutes. If they can't figure it out after a couple minutes, they can email me or we chat and I'll help them sort it out. When it comes to feeling isolated, I start work early and take a long lunch break. I go over to the college and have lunch with faculty and grad students whose work I find interesting. I give a seminar talk every now and then. I don't really feel isolated at all.