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In Slovakia (a small EU country) we have a non-profit called "Dobry anjel" (Good angel) which helps families of children sick with cancer and other serious diseases. It is also collects donations, is separately funded and distributes all the donations "up to the last cent". Two possibly interesting tidbits: 1) The organization has re-distributed almost 17 million euros since its inception in 2006 (this is 23 mil. USD, over half a million USD in the last month alone -- our population is about the same as Minnesota), 2) Its co-founder Andrej Kiska is planning to run for president of Slovakia next year.

EDIT: Note on transparency: all the donors have their own website login information ("angel ID") to track every donation and see exactly how much was sent to whom. The stories of recipient families are provided, along with their address + telephone number. The donors have an option to remain anonymous or reveal their contact information. I never contacted any recipients or revealed my name to them but I have heard stories where the donors and families in distress got in touch and supported each other with prayers, encouragements, etc.. "Good angel" also makes it possible to keep sending donations to the same families if you choose to (otherwise the families will be chosen at random, which is the default choice -- or at least was the default for me when I signed up in 2007).