I use More Interestingness[0] for new tabs in Chrome, and I have my personal email, work email, twitter and Google Reader start in pinned tabs on launch.
I have no need for five seconds of inspirational quotes. That's what /usr/local/bin/fortune is for.
Google search is my homepage because it is (er... 'was') lightweight and quick to load. When opening the browser, if there was a problem with my net connection, I could be fairly certain it was between me and the ISP, not that the google servers were down.
Yeah, I agree with the consensus thus far. To me the sign-up ruins this. Anything that gets this to the point where that's not required, adds a lot of value to your service.
http://www.fivesecondhomepage.com/www.reddit.com
Which shows the quote, then gets me to reddit or whatever